منابع مشابه
Statins and cognitive impairment.
Evidence • A systematic review of 57 studies (19 RCTs, 26 cohort studies, 6 case-control studies, and 6 cross-sectional studies)1 showed the following: -1 RCT (20 536 patients) showed no effect on incidence of dementia or cognitive impairment. -Observational studies reported that statins reduced the incidence. In 10 cohort studies of 4 360 137 patients, the relative risk was 0.87 (95% CI 0.82 t...
متن کاملStatins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria
Cerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection in children and non-immune adults. Previous work has documented a persistent cognitive impairment in children who survive an episode of CM that is mimicked in animal models of the disease. Potential therapeutic interventions for this complication have not been investigated, and are urgently needed. HMG-CoA...
متن کاملThe effect of statins on rate of cognitive decline in mild cognitive impairment
OBJECTIVE This study's aims are to identify whether or not a relationship between statin use and rate of cognitive decline exists. BACKGROUND The relationship between statins and MCI has been investigated in the past with the evidence showing mixed results. METHODS 768 subjects were identified with MCI. Subjects were stratified into 6 possible groups according to ApoE4 status and statin use...
متن کاملUse of statins and incidence of dementia and cognitive impairment without dementia in a cohort study.
OBJECTIVE Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS Data were from a population-based cohort study comprising 1,789 older Mexican Americans. All participants had cognitive...
متن کاملImpairment without Dementia in a Cohort Study Use of Statins and Incidence of Dementia and Cognitive
2009;72;1190-1191 Neurology Kalbfleisch, K. Langa and S. Galea Mark R. Goldstein, Luca Mascitelli, Francesca Pezzetta, M.N. Haan, C. Cramer, J. IMPAIRMENT WITHOUT DEMENTIA IN A COHORT STUDY USE OF STATINS AND INCIDENCE OF DEMENTIA AND COGNITIVE This information is current as of April 6, 2009 http://www.neurology.org/cgi/content/full/72/13/1190 located on the World Wide Web at: The online versio...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2019
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2019.09.040